INHIBITION OF BACTERIAL GROWTH BY d-LEUCINE
نویسندگان
چکیده
منابع مشابه
INHIBITION OF BACTERIAL GROWTH BY d-LEUCINE*
The present study was undertaken as one approach to an elucidation of the effective structure of the antibiotic, gramicidin (1). The results of investigations of this sort are expected to lead to improved antibiotics, and to experimental approaches to the paths of biological synthesis of ,protein. A striking feature of gramicidin is its content of d-amino acids, notably d-leucine (2). The prese...
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In previous reports (I, 2), data were presented on the growth response of a leucineless mutant (strain 679-680)’ of Escherichia coli strain K-12 to various L-leucine peptides. Measurement of the extent of bacterial growth after 24 hours incubation showed that, at low concentrations, the peptides were almost as effective in the stimulation of growth as was L-leucine; at high concentrations, howe...
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Experiments in tivo have demonstrated that animals are able to invert certain n-amino acids to their natural forms (l-4). This inversion has been repeatedly confirmed in studies with different species of animals by their ability to utilize the D enantiomorphs for t-he purposes of growth or maintenance of nitrogen equilibrium. In the case of the rat, the D isomers of histidine (5, 6), methionine...
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1 Generously provided by the Win. S. Merrell involved. Since casein hydrolyzate showed conCompany under their trade name of Meratran. siderable activity, and since the activity of It is [a-(2-piperidyl) benzhydrol] hydrochloride, a yeast extract was destroyed by nitrous acid and central stimulant, and is water-soluble and therto some extent by 1 N NaOH, but not by 1 N mostable. HCI, it seemed p...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1944
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)51176-5